NRP 49 "Antibiotic resistance"
The National Research Programme "Antibiotic resistance" (NRP 49) intended to focus on establishing scientific strategies and new methods applicable to a prospective system of resistance monitoring and on the analysis of the current situation concerning resistance in Switzerland, in all relevant areas (human and animal populations, agriculture, foodstuffs and the environment). The mobility of resistant bacteria or resistance genes and the resulting risk for future therapies have been evaluated.
Molecular studies on the emergence of antibiotic resistance provided new knowledge for the development of new antibiotics and new methods of in vitro detection. Furthermore, social, legal, ethical and economical consequences of the development of antibiotic resistance and a possible modification of rulings on the use of antibiotics have been estimated.
Facts & figures
Framework
CHF 12'000'000
Duration
5 years
President of the steering committee
Jean-Claude Piffaretti, Interlifescience, Massagno
Implementation Officer
Francesco Lurati, Università della Svizzera italiana, Lugano
Programme Coordinator
Barbara Flückiger Schwarzenbach, SNSF
Work launch
July 2001
End of research
June 2006
Final reports
- Final Report of NRP 49 (PDF, 5.7 MB) (PDF)
- anresis.ch website (Swiss Centre for Antibiotic resistance)
Final reports
Human and veterinary medicine
Occurrence of human-use antibiotics and antibiotic resistance in the aquatic environment (HUMABRA) (PDF)Prof. Dr. Walter Giger, EAWAG, Dübendorf
An interventional study to evaluate the impact of a rapid on-admission screening strategy in preventing nosocomial MRSA infection (PDF)PD Dr. Stephan Harbarth, Service Prévention et Contrôle de l’Infection, Direction médicale, Hôpitaux Universitaires de Genève
Antibiotic resistance genes in food: Molecular identification and transfer between micro-organisms (ABRFOOD) (PDF)Prof. Dr. Leo Meile, Institut für Lebensmittel- und Ernährungswissenschaften (ILW), Labor für Lebensmittelbiotechnologie, ETH Zürich
Sentinel surveillance of antibiotic resistance in Switzerland (SEARCH) (PDF)Prof. Dr. Kathrin Mühlemann, Institut für Infektionskrankheiten, Universität Bern
Role of residual antibiotics in aquatic environments on selection and diffusion of bacterial resistances (RASDI) (PDF)Prof. Dr. Raffaele Peduzzi, Istituto Cantonale di Microbiologia, Bellinzona
Assessment of antibiotic use and antibiotic resistance in long-term care facilities (PDF)Prof. Dr. Christian Ruef, Klinik für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich
Evolution of macrolide resistance of enterococci isolated from faeces of calves fed with antibiotic contaminated milk (PDF)Prof. Dr. Melchior Schällibaum, Agroscope Liebefeld-Posieux, Eidg. Forschungsanstalt für Nutztiere & Milchwirtschaft (ALP), Bern
Induction and spread of antibiotic resistance in livestock (PDF)Dr. Christian Stamm, EAWAG, Dübendorf
Development of an optimal strategy for monitoring antimicrobial resistance in bacteria from food animals in Switzerland (PDF)Dr. Katharina Stärk Spallek, Bundesamt für Veterinärwesen (BVET), Bern
Molecular biology
Genetic basis of glycopeptide resistance in Staphylococcus aureus (PDF)Prof. Dr. Brigitte Berger-Bächi, Universität Zürich, Institut für Medizinische Mikrobiologie
Identification of ribosomal mechanisms mediating drug resistance (PDF)Prof. Dr. Erik Christian Böttger, Universität Zürich, Institut für Medizinische Mikrobiologie
Rapid characterisation of methicillin-resistant Staphylococcus aureus clinical isolates for an improved drug prescription (PDF)Prof. Dr. Patrice François, Laboratoire de Recherche Génomique, Service des Maladies Infectieuses, Hôpitaux Universitaires de Genève
Antimicrobial resistance in Bacilli, transfer and detection (PDF)Prof. Dr. Joachim Frey, Institut für Veterinärbakteriologie, Universität Bern
Effect of teicoplanin resistance on host response to Staphylococcus aureus (PDF)Prof. Dr. Regine Landmann-Suter, Departement Forschung, Abteilung Infektiologie, Universitätsspital Basel
Targeting tuberculosis inside its host cells (PDF)Prof. Dr. Jean Pieters, Biozentrum, University of Basel
Molecular evolution of pathogenicity and resistance in Escherichia coli (PDF)Prof. Dr. Jean-Claude Piffaretti, Istituto Cantonale di Microbiologia, Bellinzona
Resistance of the fungal pathogen Aspergillus fumigatus to antifungal agents (PDF)Prof. Dr. Dominique Sanglard, Institut de Microbiologie de l’Université de Lausanne
Overcoming intrinsic multidrug resistance to discover and expand the repertoire of antibiotics active against mycobacterial pathogens (PDF)Prof. Dr. Charles J. Thompson, Prof. Dr. Stephan Grzesiek, Biozentrum, University of Basel, Division of Molecular Microbiology
Novel approaches to detect and circumvent antibiotic resistance in Pseudomonas aeruginosa (PDF)Dr. Christian van Delden, Département de Médecine, Division des Maladies Infectieuses, Hôpital Cantonal Universitaire, Genève
Mechanisms of glycopeptide resistance in staphylococci (PDF)Dr. Pierre Vaudaux, Division des Maladies Infectieuses, Hôpital Cantonal Universitaire de Genève
Society, law and economies
Economic analysis of outpatients’ antibiotic consumption in Switzerland (PDF)Prof. Dr. oec. publ. Massimo Filippini, Istituto di Finanza, Facoltà di economia, Università della Svizzera italiana, Lugano
Biological terrorism and crisis management in Switzerland – Lessons learned from the anthrax alert and steps ahead (PDF)Dr. Jan Metzger, Forschungsstelle für Sicherheitspolitik ETH Zürich
Towards judicious use of antibiotics by doctors and patients (PDF)Prof. Dr. Peter Schulz, Institute of Communication and Health, Facoltà di scienze della comunicazione, Università della Svizzera Italiana, Lugano
Prediction and predictability of resistance to antibiotics: Studies based on coupled map lattices (PDF)PD. Dr. John Shiner, Hettiswil
Legal implications of antibiotic resistance: Analysis of Swiss legislation and comparative law (D, F, UK) (PDF)Prof. Dr. jur. Dominique Sprumont, Institut de droit de la santé, Université de Neuchâtel
Individual decision on antibiotic treatment. A case for utility assessment (PDF)Prof. Dr. Dominik Uehlinger, Klinik und Poliklinik für Nephrologie und Hypertonie, Universität Bern, Inselspital, Bern
Use of antibiotics in Switzerland: Investigation of a monitoring system (PDF)MD Giorgio Zanetti, Service of Infectious Diseases and Division of Hospital Preventive Medicine, University Hospital, Lausanne