NRP 50 "Endocrine Disruptors: Relevance to Humans, Animals and Ecosystems"
The National Research Programme "Endocrine Disruptors: Relevance to Humans, Animals and Ecosystems" (NRP 50) aimed to develop scientific strategies to assess the risks and hazards that arise when endocrine disruptors are processed through ecosystems to cause human and animal exposure. Methods and models suitable to assess the endocrine activity of these chemicals or chemical mixtures were established and the mechanisms of action, and their effects on developmental and reproductive processes were investigated. The magnitude of exposure of humans, domestic animals, wildlife and environment in Switzerland and the resulting hazards and risks were assessed. The NRP aimed to create a consensus platform for industry and regulators on how to avoid the negative impact of today's chemicals of this category. In the pursuit of this goal, the NRP aimed to define a set of rules for future development of pertinent substances.
Facts & Figures
Framework
CHF 15'000'000
Duration
5 Years
President of the steering comittee
Felix R. Althaus, Institut für Pharmakologie und Toxikologie, Veterinärmedizinische Fakultät, Universität Zürich
Implementation Officer
Marcel Trachsel, int/ext Communications AG, Basel
Programme coordinator
Barbara Flückiger, FNS
Work launch
January 2002
End of research
June 2007
Further information and final report
Final Report of NRP 50
Final reports of the Consensus Platforms
Special issue CHIMIA 62 (2008)
- Editorial: Relevance to Humans, Animals and Ecosystems; Research Highlights from the National Research Programme NRP50, Guest Editors: Felix R. Althaus, Konrad Hungerbühler, Susan Jobling, Urs Ruegg, Ana Soto, Christoph Studer (PDF)
- Endocrine disruptors: Introduction, Felix R. Althaus, Chimia 62 (2008) 318–321 (PDF)
- VirtualToxLab – in silico Prediction of the Endocrine-Disrupting Potential of Drugs and Chemicals, Angelo Vedani*, Morena Spreafico, Ourania Peristera, Max Dobler, and Martin Smiesko, Chimia 62 (2008) 322–328 (PDF)
- Identification of Endocrine-Disrupting Compounds Using Nanoelectrospray Ionization Mass Spectrometry, Cédric Bovet, Marc Ruff, Arno Wortmann, Sylvia Eiler, Florence Granger, Bertran Gerrits, Dino Moras, and Renato Zenobi, Chimia 62 (2008) 329–334 (PDF)
- Disruption of Glucocorticoid and Mineralocorticoid Receptor-Mediated Responses by Environmental Chemicals, Alex Odermatt* and Christel Gumy, Chimia 62 (2008) 335–339 (PDF)
- PPAR Disruption: Cellular Mechanisms and Physiological Consequences, Nicolas Rotman, Zofia Haftek-Terreau, Sandra Lücke, Jérôme Feige, Laurent Gelman, Béatrice Desvergne, and Walter Wahli, Chimia 62 (2008) 340–344 (PDF)
- Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk; Margret Schlumpf, Karin Kypke, Claudia C. Vökt, Monika Birchler, Stefan Durrer, Oliver Faass, Colin Ehnes, Michaela Fuetsch, Catherine Gaille, Manuel Henseler, Luke Hofkamp, Kirsten Maerkel, Sasha Reolon, Armin Zenker, Barry Timms, Jesus A. F. Tresguerres, and Walter Lichtensteiger, Chimia 62 (2008) 345–351 (PDF)
- Brominated Flame Retardants – Endocrine-Disrupting Chemicals in the Swiss Environment; Andreas C. Gerecke, Peter Schmid, Christian Bogdal, Martin Kohler, Markus Zennegg, and Norbert V. Heeb, Chimia 62 (2008) 352–357 (PDF)
- ipso-Substitution – A Novel Pathway for Microbial Metabolism of Endocrine-Disrupting 4-Nonylphenols, 4-Alkoxyphenols, and Bisphenol A; Hans-Peter E. Kohler, Frédéric L. P. Gabriel, and Walter Giger, Chimia 62 (2008) 358–363 (PDF)
- Environmental Exposure to Estrogenic and other Myco- and Phytotoxins; Niccolo Hartmann, Marianne Erbs, Felix E. Wettstein, Corinne C. Hörger, Susanne Vogelgsang, Hans-Rudolf Forrer, René P. Schwarzenbach, and Thomas D. Bucheli, Chimia 62 (2008) 364–367 (PDF)
- UV Filters in the Aquatic Environment Induce Hormonal Effects and Affect Fertility and Reproduction in Fish; Karl Fent, Petra Y. Kunz, and Elena Gomez. Chimia 62 (2008) 368–375 (PDF)
- Estrogenic Endocrine Disruption in Switzerland: Assessment of Fish Exposure and Effects; Patricia Burkhardt-Holm*, Helmut Segner, Richard Burki, Armin Peter, Sara Schubert, Marc J.-F. Suter, and Mark E. Borsuk, Chimia 62 (2008) 376–382 (PDF)
- Estrogens in Swiss Rivers and Effluents – Sampling Matters; Etiënne L. M. Vermeirssen, Rik I. L. Eggen, Beate I. Escher, and Marc J.-F. Suter, Chimia 62 (2008) 389–394 352–357 (PDF)
- First Evaluation of Human Sperm Quality in Various Geographic Regions of Switzerland; Michel Crausaz, Josefina Vargas, Roumen Parapanov, Yves Chollet, Marc Wisard, Eric Stettler, Alfred Senn, and Marc Germond, Chimia 62 (2008) 395–400 (PDF)
- Diethylstilbestrol Action on Leydig Cell Function and Testicular Descent; Christopher R. Cederroth and Serge Nef, Chimia 62 (2008) 401–405 (PDF)
- Endocrine Disruptors and Breast Cancer; Cathrin Brisken, Chimia 62 (2008) 406–409 (PDF)
- Genetic Reprogramming of Human Mammary Cells by Environmental Carcinogens Released into Breast Milk; Ramiro Dip, Tonko Buterin, Daniela Wenger, Peter Schmid, and Hanspeter Naegeli, Chimia 62 (2008) 410–416 (PDF)
- Integrative Risk Assessment of Endocrine Disruptors in Switzerland; René Gälli and Christian Braun, Chimia 62 (2008) 417–423 (PDF)
- Dynamic Substance Flow Analysis as a Valuable Risk Evaluation Tool – A Case Study for Brominated Flame Retardants as an Example of Potential Endocrine Disrupters; Leo S. Morf, Andreas M. Buser, Ruedi Taverna, Hans-Peter Bader, and Ruth Scheidegger, Chimia 62 (2008) 424–431 (PDF)
- Results of the Consensus Platforms: Positions and Recommendations Derived from Scientific Findings in a Joint Effort of Academics, Industry, and Authorities; Marcel Trachsel, Chimia 62 (2008) 432–438 (PDF)